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Inhibrx to Unveil HexAgon Phase 2 Results for HNSCC Treatment

San Diego-based Inhibrx Biosciences will host a live webcast on September 8, 2026, at 5:00 a.m. PT to disclose primary endpoint data from its HexAgon study. The trial evaluates INBRX-106, a hexavalent OX40 agonist, in combination with pembrolizumab for patients with metastatic or unresectable head and neck squamous cell carcinoma.

Inhibrx to Unveil HexAgon Phase 2 Results for HNSCC Treatment
Photo: Bio & News

The study compares the efficacy and safety of the INBRX-106 combination therapy against pembrolizumab monotherapy in treatment-naïve patients expressing PD-L1 with a Combined Positive Score of at least 20. Designed to address the limitations of traditional bivalent antibodies, INBRX-106 uses a proprietary single-domain platform to achieve high-order receptor clustering, which the company claims is essential for robust T-cell activation and survival.

Investors can access the presentation through the company’s investor relations portal or by dialing 1-888-880-3330 using conference ID 6981384. Following the live session, the data and updated corporate slides will remain available on the Inhibrx website for 60 days. This clinical milestone represents a key assessment of the company’s multivalent approach to protein engineering, which also includes the development of ozekibart.

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