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Johnson & Johnson reports TREMFYA success in axial psoriatic arthritis study

Johnson & Johnson announced that its drug TREMFYA has become the first IL-23 inhibitor to demonstrate significant improvements in spinal pain and stiffness for patients with axial psoriatic arthritis. The Phase 4 STAR study utilized objective MRI assessments to confirm a reduction in inflammation among biologic-naïve adults.

Johnson & Johnson reports TREMFYA success in axial psoriatic arthritis study
Photo: Bio & News

The STAR trial represents a shift in how researchers evaluate treatment efficacy for axial psoriatic arthritis, a condition that affects the spine and sacroiliac joints. By incorporating MRI imaging to track inflammation, the study provided measurable evidence of the drug's impact beyond subjective patient reports. Participants in the study, all of whom had active disease, showed consistent improvement in symptoms including fatigue and physical function over the 24-week period compared to those receiving a placebo.

David M. Lee, head of the immunology therapeutic area at Johnson & Johnson, noted that the data addresses a critical gap in care for a patient population often struggling with limited mobility and chronic pain. While current treatment options for psoriatic arthritis are available, axial involvement remains difficult to manage due to a lack of standardized classification criteria. The company plans to present the full efficacy and safety findings at an upcoming scientific congress, confirming that the drug's safety profile remained consistent with previous clinical observations.

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