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Elicio Therapeutics Shares Plunge Following Failed Pancreatic Cancer Trial

Shares of Elicio Therapeutics cratered 51% in premarket trading Monday, sinking to $7.30 after the company announced its lead experimental treatment failed to meet primary endpoints in a phase 2 clinical trial involving patients with pancreatic ductal adenocarcinoma, the most aggressive form of the disease.

Elicio Therapeutics Shares Plunge Following Failed Pancreatic Cancer Trial

The Amplify-7P study, designed to evaluate the efficacy of ELA-002 7P as an adjuvant treatment, missed its prespecified target for disease-free survival. Despite the primary failure, the company noted that post-hoc analyses identified a more robust therapeutic signal among the 84% of participants who underwent complete tumor resection with clear surgical margins. Elicio management indicated these insights are now being used to sharpen the focus of a planned phase 3 strategy, which will incorporate adjusted dosing regimens. To support these future efforts, the biotechnology firm is actively exploring strategic financing and potential partnership opportunities to bankroll subsequent late-stage testing.

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